[ 8th September 2022 by Jiayu Zhang 0 Comments ]

The cactus cladode (Opuntia ficus indica) modulates uricemia, improves endothelial dysfunction and corrects oxidative damage in rats fed a cafeteria diet, Hadjera Chekkal, Dr. Nour Harrat, Dr. Fatima Bensalah, Dr. Fouad Affane, Dr. Sabrine Louala and Prof. Myriem Lamri-Senhadji

Hadjera Chekkal, Dr. Nour el Imane Harrat, Dr. Fatima Bensalah, Dr. Fouad Affane, Dr. Sabrine Louala, Prof. Myriem Lamri-Senhadji
Biology, Faculté des Sciences de la Nature et de la Vie, Laboratoire de Nutrition Clinique et Métabolique (LNCM)
Université Oran1 Ahmed Ben Bella Oran, Oran
Email: mylamri@hotmail.fr

DOI: 10.1108/WJSTSD-05-2019-0023

Purpose: The effects of Opuntia ficus indica (OFI) cladodes on uricemia level, endothelial dysfunction and oxidative damage were studied in young rats fed a cafeteria diet (CD).
Design/methodology/approach: A total of 16 young male Wistar rats (weighing 110 ± 20 g and four weeks old) were divided into two homogenous groups. The first group received a CD containing 50% of hyperlipidic diet and 50% of junk food mix (processed mix: hyper-fat, hyper-salted and sweetened) (CD group), and the second group (CD + OFI nopalitos) received the same diet supplemented with 50 g of fresh OFI nopalitos (young cladodes) for 30 days.
Findings: OFI nopalitos regulate the hyperuricemia, improve the endothelial dysfunction by raising the bioavailability of nitric oxide(NO) and reduce prooxidant markers by reducing lipid peroxidation and protein oxidation (p < 0.05) and boosting antioxidant capacity and enhancing the antioxidant enzymes activities (p < 0.05) in blood and aorta tissues of rats early fed with a high-fat diet /junk food.
Social implications: By-products of OFI have specific functional properties that may be beneficial in metabolic disorders and offer a better alternative with an economic and sustainable development perspective.
Originality/value: By-products of OFI highlight potential functional properties mainly based on its potent antioxidant capacity. By-products of OFI can be used as a promising nutraceutical resource to prevent various metabolic disorders in relation with cardiovascular diseases or hyperuricemia in subjects consuming junk food and or living in the Western society to reach the objectives of health policy and maintain a sustainable health system development.
Keywords: Opuntia ficus indica; By-products; Oxidative stress; Endothelial dysfunction; Hyperuricemia; Junk food.
Citation: Chekkal, H., Harrat, N.e.I., Bensalah, F., Affane, F., Louala, S. and Lamri-Senhadji, M. (2020), "The cactus cladode (Opuntia ficus indica) modulates uricemia, improves endothelial dysfunction and corrects oxidative damage in rats fed a cafeteria diet", World Journal of Science, Technology and Sustainable Development, Vol. 17 No. 4, pp. 355-365. https://doi.org/10.1108/WJSTSD-05-2019-0023


WJSTSD V17 N4 2020 Chekkal et al.pdf
WJSTSD V17 N4 2020 Chekkal et al.pdf
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