Effect of Polyethylene Terephthalate Microplastic on Rat Isolated Tissue Function and Liver Enzyme, Man Yee

Man Yee
University of Nottingham Malaysia
Malaysia

Abstract: Microplastic pollution has emerged as a pervasive threat to both the environment and human health, with far-reaching implications for the well-being of future generations. Polyethylene terephthalate (PET) microplastic is one of the most abundant microplastics found in ecosystems, and it raises concerns due to its persistence and potential biological impacts. As the youth population grows rapidly and stands at the forefront of tomorrow’s society, understanding the effects of microplastic exposure is essential for shaping a healthier and more sustainable future. My research investigated the effects of PET microplastics on tissue function and liver enzymes activity to gain insights into the potential health risks that today’s youth and generations face. Using a rat model, I assessed the changes in contraction and relaxation responses in key organ systems, specifically the trachea, bladder, and aorta, following exposure to PET microplastics. These organs were selected due to their fundamental physiological roles. Additionally, CYP450 enzyme activity was examined to better understand how microplastic exposure may disrupt normal biological processes at the molecular level. The results showed significant impacts on tissue function in certain concentrations of microplastic exposure, as well as inhibition of certain enzyme activity, indicating that PET microplastics can impair vital function. This may cause possible implications for human health if similar effects occur on the human body. This research emphasizes the urgent need to address microplastic contamination not only as an environmental crisis but also as a public health concern. By studying the potential biological effects of PET microplastics, my study hopes to empower youth with scientific knowledge and inspire action towards sustainable development. Ultimately, to encourage young people to take an active role in combating plastic pollution for a safer and more resilient future.