Gum Arabic More Than Emulsifier and Food Additive; A New Experimental Validation of Anti-Proliferative against Colorectal Colon Cancer Cell Lines: Part 2, Dr. A.A.M. Elnour, Dr. M.E.S. Mirghani, Dr. N.A. Kabbashi, Dr. Md.Z. Alam, D. Daddiouaissa, Dr. K.H. Musa and Dr. N.H. Abdurahman

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Dr. A.A.M. Elnour

International Islamic university, Malaysia and university of kordofan

Sudan

Dr. M.E.S. Mirghani

International Islamic University

Malaysia

Dr. N.A. Kabbashi

International Islamic University

Malaysia

Dr. Md.Z. Alam

International Islamic University

Malaysia

D.Daddiouaissa

International Islamic University

Malaysia

Dr. K.H. Musa

Qassim university

United Arab Emirates

Dr. N.H. Abdurahman

Universiti Malaysia Pahang Gambang

Malaysia

Purpose: The aim of this paper is to discover the cytotoxicity activity of Acacia seyal gum  and  Pre-bio-T-commercial (PTC) samples on human colon cancer (HCT-116) cell lines; in addition, its  polyphenolic properties are investigated.

Approach: The methodology used in this paper involves fractionating methanol crude extracts of both Acacia seyal gum and Prebio-T-commercial into methanol, respectively. The cytotoxicity activity on human colon cancer cell lines for each fraction has been studied using sul-forhodamine B assay (SRB assay) . Both samples, Acacia seyal gum and  Prebio-T-commercial  (PTC), have been analysed precisely using high performance liquid chromatography (HPLC)  technique.

Findings: Based on the analysis, more cytotoxicity activity was identified in the sample obtained from Acacia seyal gum (IC50=13.36μg/mL)compared to PTC(IC50=17.18μg/mL). Regarding the flavonoids content(FC), quercetin was the only flavonoids detected in the samples, found to be approximate of 4,640μg/100g for Acacia seyal gum, almost double value of 2,560μg/100g for PTC.

Implications: The implications of this study are the evidence of flavonoids content and anti-cancer activity for both Acacia seyal gum and PTC used in folk medicine, as well as anticipation of cancer cell growth. It is expected that the proposed methods will give a noble contribution to the possible use of their bioactive compounds as natural anti- cancer agents.

Citation: Elnour. A. A. M., Mirghani. M. E. S., Kabbashi. N. A., Alam. M. Z., Daddiouaissa. D., Musa. K. H. and Abdurahman. N. H.: Gum Arabic More Than Emulsifier and Food Additive; A New Experimental Validation of Anti-Proliferative against Colorectal Colon Cancer Cell Lines: Part 2. In Allam Ahmed(Ed.): Home-Books-Proceedings-SDC, Vol. 1, pp. 14. WASD: Brighton, United Kingdom.